Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse

Anna D. Senft; Elizabeth K. Bikoff; Elizabeth J. Robertson; Ita Costello

doi:10.1038/s41467-019-09052-w

Nature Communications (Mar 2019)

Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse

Anna D. Senft,
Elizabeth K. Bikoff,
Elizabeth J. Robertson,
Ita Costello

Affiliations

Anna D. Senft: Sir William Dunn School of Pathology, University of Oxford
Elizabeth K. Bikoff: Sir William Dunn School of Pathology, University of Oxford
Elizabeth J. Robertson: Sir William Dunn School of Pathology, University of Oxford
Ita Costello: Sir William Dunn School of Pathology, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-09052-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 controls PGC migration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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