STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

Paula Nunes-Hasler; Sophia Maschalidi; Carla Lippens; Cyril Castelbou; Samuel Bouvet; Daniele Guido; Flavien Bermont; Esen Y. Bassoy; Nicolas Page; Doron Merkler; Stéphanie Hugues; Denis Martinvalet; Bénédicte Manoury; Nicolas Demaurex

doi:10.1038/s41467-017-01600-6

Nature Communications (Nov 2017)

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

Paula Nunes-Hasler,
Sophia Maschalidi,
Carla Lippens,
Cyril Castelbou,
Samuel Bouvet,
Daniele Guido,
Flavien Bermont,
Esen Y. Bassoy,
Nicolas Page,
Doron Merkler,
Stéphanie Hugues,
Denis Martinvalet,
Bénédicte Manoury,
Nicolas Demaurex

Affiliations

Paula Nunes-Hasler: Department of Cell Physiology and Metabolism, University of Geneva
Sophia Maschalidi: Laboratory of Normal and Pathological Homeostasis of the Immune System, INSERM UMR1163
Carla Lippens: Department of Pathology and Immunology, University of Geneva
Cyril Castelbou: Department of Cell Physiology and Metabolism, University of Geneva
Samuel Bouvet: Department of Cell Physiology and Metabolism, University of Geneva
Daniele Guido: Department of Cell Physiology and Metabolism, University of Geneva
Flavien Bermont: Department of Cell Physiology and Metabolism, University of Geneva
Esen Y. Bassoy: Department of Cell Physiology and Metabolism, University of Geneva
Nicolas Page: Department of Pathology and Immunology, University of Geneva
Doron Merkler: Department of Pathology and Immunology, University of Geneva
Stéphanie Hugues: Department of Pathology and Immunology, University of Geneva
Denis Martinvalet: Department of Cell Physiology and Metabolism, University of Geneva
Bénédicte Manoury: Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine Paris Descartes
Nicolas Demaurex: Department of Cell Physiology and Metabolism, University of Geneva

DOI: https://doi.org/10.1038/s41467-017-01600-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and provide a mechanism for its requirement in antigen cross-presentation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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