Complex small-world regulatory networks emerge from the 3D organisation of the human genome

C. A. Brackley; N. Gilbert; D. Michieletto; A. Papantonis; M. C. F. Pereira; P. R. Cook; D. Marenduzzo

doi:10.1038/s41467-021-25875-y

Nature Communications (Oct 2021)

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

C. A. Brackley,
N. Gilbert,
D. Michieletto,
A. Papantonis,
M. C. F. Pereira,
P. R. Cook,
D. Marenduzzo

Affiliations

C. A. Brackley: SUPA, School of Physics and Astronomy, University of Edinburgh
N. Gilbert: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital
D. Michieletto: SUPA, School of Physics and Astronomy, University of Edinburgh
A. Papantonis: Institute of Pathology, University Medical Center, Georg-August University of Göttingen
M. C. F. Pereira: SUPA, School of Physics and Astronomy, University of Edinburgh
P. R. Cook: Sir William Dunn School of Pathology, University of Oxford
D. Marenduzzo: SUPA, School of Physics and Astronomy, University of Edinburgh

DOI: https://doi.org/10.1038/s41467-021-25875-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Gene-regulatory networks are thought to be complex, and yet perturbation of just a few transcription factors (TFs) can have major consequences. Here the authors apply DNA polymer modelling and simulations to predict how 3D genome structure and TF-DNA interactions can give rise to transcriptional regulation operating over broad genomic regions, where small perturbations can have long-reaching effects.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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