Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
Usama Fathy,
Hayam A. Abd El Salam,
Eman A. Fayed,
Abdelbaset M. Elgamal,
Ahmed Gouda
Affiliations
Usama Fathy
Applied Organic Chemistry Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.), Dokki-Giza, P.O.12622, Egypt; Corresponding author.
Hayam A. Abd El Salam
Green Chemistry Department Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.), Dokki-Giza, P.O.12622, Egypt
Eman A. Fayed
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, 11754, Egypt; Corresponding author.
Abdelbaset M. Elgamal
Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.), Dokki-Giza, P.O.12622, Egypt
Ahmed Gouda
Pharmaceutical Research Department, Nawah Scientific, Cairo, Egypt
Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were used to confirm the structure of synthesized compounds. Then, they were assessed in vitro against three human cancer cell lines. Consequently, four compounds, 10, 13, 15, and 16, were identified as promising anticancer agents with pyrazolo quinoline derivative (15) exhibiting the highest potential IC50 and a strong apoptotic effect on three cell lines.
