Nature Communications (Sep 2018)

Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis

  • Ronja Driller,
  • Sophie Janke,
  • Monika Fuchs,
  • Evelyn Warner,
  • Anil R. Mhashal,
  • Dan Thomas Major,
  • Mathias Christmann,
  • Thomas Brück,
  • Bernhard Loll

DOI
https://doi.org/10.1038/s41467-018-06325-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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The bacterial diterpene synthase CotB2 catalyses the cyclisation of geranylgeranyl diphosphate to cyclooctat-9-en7-ol. Here the authors present various CotB2 structures including a trapped abrupt reaction product that were used for molecular dynamic simulations and allowed them to model all intermediates along the reaction cascade.