The Utilization of Two-Phase Catalytic System in Enantioselective Biotransformation of Racemic Atenolol

Abstract

There are several methods that allow enantiomerically pure compounds to be obtained. In the study presented herein, the enantioselective biotransformations of (R,S)-atenolol were performed with the use of various catalytic systems containing ionic liquids and toluene as a reaction medium, vinyl acetate as an acetylating agent as well as lipases from Candida rugosa. The conducted studies profs that, the use of the two-phase reaction system enables the reuse of the biocatalyst in another cycle and allows to achieve satisfactory kinetic resolution parameters.

Keywords

• <i>Candida rugosa</i> lipase
• ionic liquid
• racemic atenolol
• enantioselective biotransformation