Emerging Infectious Diseases (Mar 2019)

In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark

  • Rasmus K. Hare,
  • Jan B. Gertsen,
  • Karen M.T. Astvad,
  • Kristine B. Degn,
  • Anders Løkke,
  • Marc Stegger,
  • Paal S. Andersen,
  • Lise Kristensen,
  • Maiken C. Arendrup

DOI
https://doi.org/10.3201/eid2503.180297
Journal volume & issue
Vol. 25, no. 3
pp. 577 – 580

Abstract

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We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

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