The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection

Abstract

Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here.

Keywords

• dengue
• dengue hemorrhagic fever
• prM
• ADE
• neutralization
• cleavage