Synthesis, molecular docking study and anticancer activity of novel 1,3,4-oxadiazole derivatives as potential tubulin inhibitors
Tarek A. Yousef,
Abdulrahman G. Alhamzani,
Mortaga M. Abou-Krisha,
G. Kanthimathi,
M.S. Raghu,
K. Yogesh Kumar,
M.K. Prashanth,
Byong-Hun Jeon
Affiliations
Tarek A. Yousef
College of Science, Chemistry Department, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia; Department of Toxic and Narcotic Drug, Forensic Medicine, Mansoura Laboratory, Medicolegal Organization, Ministry of Justice, Egypt
Abdulrahman G. Alhamzani
College of Science, Chemistry Department, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia
Mortaga M. Abou-Krisha
College of Science, Chemistry Department, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia; Department of Chemistry, South Valley University, Qena, 83523, Egypt
G. Kanthimathi
Department of Chemistry, Ramco Institute of Technology, Rajapalayam, Tamilnadu, 626117, India
M.S. Raghu
Department of Chemistry, New Horizon College of Engineering, Bengaluru 560 103, India
K. Yogesh Kumar
Department of Chemistry, Faculty of Engineering and Technology, Jain University, Ramanagara, 562 112, India
M.K. Prashanth
Department of Chemistry, B N M Institute of Technology, Bengaluru 560 070, India; Corresponding author.
Byong-Hun Jeon
Department of Earth Resources and Environmental Engineering, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea; Corresponding author. Department of Earth Resources and Environmental Engineering, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
The current study reports on the synthesis and anticancer efficacy of novel oxadiazole derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies were used to confirm the newly produced compounds. In contrast to the conventional medicine colchicine, compounds 8e and 8f demonstrated stronger sensitivity and improved IC50 values in the range of 3.19–8.21 μM against breast MCF-7, colorectal HCT116, and liver HepG2 cancer cell lines. The target compounds were tested for enzymatic activity against the tubulin enzyme. Compounds 8e and 8f were shown to have the most effective inhibitory action among the new compounds, with IC50 values of 7.95 and 9.81 nM, respectively. As compared to the reference drug, molecular docking investigations of the developed compounds revealed the crucial hydrogen bonding in addition to the hydrophobic interaction at the binding site, assisting in the prediction of the structural requirements for the found anticancer activity. These findings indicate that the 1,3,4-oxadizole scaffold has the potential for future research into new anticancer medicines.
