Evaluation of Parathyroid allo-transplantation with the Presence of Auto-CASR Antibody

Abstract

Objective:Parathyroid tissue is responsible for the regulation of calcium and vitamin D metabolism. It regulates parathyroid hormone release by the calcium-sensing receptor (CaSR) which is found on the parathyroid cell surface. Auto-antibody formation against this receptor has been reported in the literature. In this study; the probability of parathyroid transplantation triggering an auto-immune response against this receptor was evaluated. Individuals were screened for the presence of auto-CaSR antibodies after transplantation.Methods:The nine individuals who underwent parathyroid transplantation were evaluated for the survival rate and were screened for the possible presence of auto-CaSR antibodies. Data were determined by ELISA from peripheral blood samples. A peripheral blood sample from one healthy volunteer was included as a negative control.Results:Survival rate assessment of nine recipients was as follows; less than one month in three individuals and more than one year in six individuals. Any trace of possible auto-CaSR antibodies was not detected in any individual.Conclusion:Auto-CaSR antibody formation was not observed after parathyroid transplantation. Thus, it has been shown for the first time in the literature that the recipients did not show an autoimmune-related response after parathyroid transplantation even with having heterogeneous survival rates. Moreover, it has been shown that the symptomatic improvements of the recipients in predicting the success of parathyroid transplantation are important in determining survival rate. Larger cohort studies are required before strong conclusions can be drawn about the auto-CaSR after parathyroid transplantation.

Keywords

• parathyroid transplantation
• parathyroid hormone
• survival rate
• auto-casr antibodies