Nature Communications (Aug 2017)

CLEC5A is a critical receptor in innate immunity against Listeria infection

  • Szu-Ting Chen,
  • Fei-Ju Li,
  • Tzy-yun Hsu,
  • Shu-Mei Liang,
  • Yi-Chen Yeh,
  • Wen-Yu Liao,
  • Teh-Ying Chou,
  • Nien-Jun Chen,
  • Michael Hsiao,
  • Wen-Bin Yang,
  • Shie-Liang Hsieh

DOI
https://doi.org/10.1038/s41467-017-00356-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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The lectin receptor CLEC5A is a pattern recognition receptor that has been shown to detect dengue and Japanese encephalitis virus. Here the authors show that CLEC5A is needed for optimal ROS production, NET formation and other immune responses to Listeria monocytogenes in mice.