Tertiary lymphoid structures in cancer: maturation and induction

Yulu Chen; Yulu Chen; Yulu Chen; Yuhao Wu; Yuhao Wu; Yuhao Wu; Guorong Yan; Guorong Yan; Guorong Yan; Guolong Zhang; Guolong Zhang; Guolong Zhang

doi:10.3389/fimmu.2024.1369626

Frontiers in Immunology (Apr 2024)

Tertiary lymphoid structures in cancer: maturation and induction

Yulu Chen,
Yulu Chen,
Yulu Chen,
Yuhao Wu,
Yuhao Wu,
Yuhao Wu,
Guorong Yan,
Guorong Yan,
Guorong Yan,
Guolong Zhang,
Guolong Zhang,
Guolong Zhang

Affiliations

Yulu Chen: Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Yulu Chen: Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Yulu Chen: Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
Yuhao Wu: Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Yuhao Wu: Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Yuhao Wu: Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
Guorong Yan: Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Guorong Yan: Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Guorong Yan: Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
Guolong Zhang: Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Guolong Zhang: Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Guolong Zhang: Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China

DOI: https://doi.org/10.3389/fimmu.2024.1369626
Journal volume & issue: Vol. 15

Abstract

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Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue. Tumor-associated TLS serves as a prominent center of antigen presentation and adaptive immune activation within the periphery, which has exhibited positive prognostic value in various cancers. In recent years, the concept of maturity regarding TLS has been proposed and mature TLS, characterized by well-developed germinal centers, exhibits a more potent tumor-suppressive capacity with stronger significance. Meanwhile, more and more evidence showed that TLS can be induced by therapeutic interventions during cancer treatments. Thus, the evaluation of TLS maturity and the therapeutic interventions that induce its formation are critical issues in current TLS research. In this review, we aim to provide a comprehensive summary of the existing classifications for TLS maturity and therapeutic strategies capable of inducing its formation in tumors.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

About the journal

Abstract

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