TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import

Abstract

The human defense mechanism against pathogens involves limiting essential nutrients, such as zinc which is countered by surface receptor TdfH pirating zinc from human calprotectin. The TdfH cryo-EM structure from N. gonorrhoeae in complex with a calprotectin tetramer provides insights into the protein-protein interaction and the role of metal ions.