Prevalence of ROS1 fusion in Chinese patients with non‐small cell lung cancer

Abstract

Background The study was conducted to investigate the clinicopathological features and prevalence of ROS1 gene fusion in Chinese patients with non‐small cell lung cancer (NSCLC). Methods The presence of ROS1 fusion was assessed by quantitative real‐time PCR. Associations between ROS1 fusion and clinical characteristics were analyzed. Results In total, 6066 patients with pathologically confirmed NSCLC and ROS1 fusion test results were enrolled. The average age was 60.89 ± 10.60 years and fusion was detected in 157 (2.59%) patients. Fusion frequency was significantly correlated with age, gender, smoking status (all P 0.05). Age, smoking status, and lymph node stage were statistically significantly correlated with ROS1 fusion frequency (all P < 0.05); gender and pathology type were not significantly correlated with ROS1 fusion status after adjusting for smoking status. Conclusion An overall ROS1 fusion frequency of 2.59% was confirmed in this study. ROS1 fusion was more prevalent among younger patients, never‐smokers, and those at advanced node stages.

Keywords

• Clinicopathological features
• non‐small‐cell lung cancer
• ROS1 fusion