Drug-Eluting Balloon Angioplasty for Complex Femoropopliteal Lesions in Patients with End-Stage Renal Disease

Abstract

Introduction:The aim of this study was to investigate the safety and efficacy of drug-elicited balloon (DEB) use in the interventional treatment of patients with end-stage renal disease (ESRD) and complex femoropopliteal artery lesions.Methods:A retrospective chart review identified 30 ESRD patients who were treated for symptomatic peripheral artery disease with DEB angioplasty between September 2012 and February 2016. The inclusion criteria were having Rutherford class 2 to 6 symptoms and a critical stenosis or occlusion of the femoropopliteal artery. While restenosis or reocclusion was the primary end point, major or minor amputation was the secondary end point.Results:A total of 36 diabetic patients with complex femoropopliteal lesions who underwent endovascular therapy with DEB were identified. Four patients were lost during follow-up and 30 patients were included in the study. The mean lesion length was 114.6±27.8 mm. Primary patency was 73.1% and the secondary end point was 10.7% at 1-year. After a mean follow-up of 16.0±5.0 months, all-cause mortality was 7.1% (n=2). Ankle-brachial index increased from 0.42±0.04 to 0.88±0.05 postoperatively.Conclusion:DEB angioplasty is efficient and safe even in long and calcified obstructive lesions including the distal superficial femoral and popliteal artery in patients with ESRD.

Keywords

• Balloon angioplasty
• drug-eluting balloon
• endstage renal disease
• peripheral interventions