A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
Lea Ankri,
Zoé Husson,
Katarzyna Pietrajtis,
Rémi Proville,
Clément Léna,
Yosef Yarom,
Stéphane Dieudonné,
Marylka Yoe Uusisaari
Affiliations
Lea Ankri
Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
Zoé Husson
Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
Katarzyna Pietrajtis
Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Cerebellum Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
Clément Léna
Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Cerebellum Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
Yosef Yarom
Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
Stéphane Dieudonné
Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
Marylka Yoe Uusisaari
Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.
