Nature Communications (Oct 2019)
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
- Yulin Shi,
- Songqing Fan,
- Mengge Wu,
- Zhixiang Zuo,
- Xingyang Li,
- Liping Jiang,
- Qiushuo Shen,
- Peifang Xu,
- Lin Zeng,
- Yongchun Zhou,
- Yunchao Huang,
- Zuozhang Yang,
- Jumin Zhou,
- Jing Gao,
- Hu Zhou,
- Shuhua Xu,
- Hongbin Ji,
- Peng Shi,
- Dong-Dong Wu,
- Cuiping Yang,
- Yongbin Chen
Affiliations
- Yulin Shi
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- Songqing Fan
- Department of Pathology, the Second Xiangya Hospital, Central South University
- Mengge Wu
- Kunming Medical University
- Zhixiang Zuo
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University
- Xingyang Li
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University
- Liping Jiang
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- Qiushuo Shen
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- Peifang Xu
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- Lin Zeng
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- Yongchun Zhou
- Kunming Medical University
- Yunchao Huang
- Kunming Medical University
- Zuozhang Yang
- Kunming Medical University
- Jumin Zhou
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- Jing Gao
- Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Hu Zhou
- Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Shuhua Xu
- Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Hongbin Ji
- Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Peng Shi
- Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences
- Dong-Dong Wu
- Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences
- Cuiping Yang
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- Yongbin Chen
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
- DOI
- https://doi.org/10.1038/s41467-019-12801-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.
