Nature Communications (Mar 2017)
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy
- Natalie A. Afshari,
- Robert P. Igo,
- Nathan J. Morris,
- Dwight Stambolian,
- Shiwani Sharma,
- V. Lakshmi Pulagam,
- Steven Dunn,
- John F. Stamler,
- Barbara J. Truitt,
- Jacqueline Rimmler,
- Abraham Kuot,
- Christopher R. Croasdale,
- Xuejun Qin,
- Kathryn P. Burdon,
- S. Amer Riazuddin,
- Richard Mills,
- Sonja Klebe,
- Mollie A. Minear,
- Jiagang Zhao,
- Elmer Balajonda,
- George O. Rosenwasser,
- Keith H Baratz,
- V. Vinod Mootha,
- Sanjay V. Patel,
- Simon G. Gregory,
- Joan E. Bailey-Wilson,
- Marianne O. Price,
- Francis W. Price,
- Jamie E. Craig,
- John H. Fingert,
- John D. Gottsch,
- Anthony J. Aldave,
- Gordon K. Klintworth,
- Jonathan H. Lass,
- Yi-Ju Li,
- Sudha K. Iyengar
Affiliations
- Natalie A. Afshari
- Shiley Eye Institute, University of California
- Robert P. Igo
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Nathan J. Morris
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Dwight Stambolian
- Department of Ophthalmology, University of Pennsylvania
- Shiwani Sharma
- Department of Ophthalmology, Flinders Medical Centre, Flinders University
- V. Lakshmi Pulagam
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Steven Dunn
- Michigan Cornea Consultants, PC
- John F. Stamler
- Department of Ophthalmology, University of Iowa, College of Medicine
- Barbara J. Truitt
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Jacqueline Rimmler
- Duke Molecular Physiology Institute, Duke University Medical Center
- Abraham Kuot
- Department of Ophthalmology, Flinders Medical Centre, Flinders University
- Christopher R. Croasdale
- Davis Duehr Dean Clinic
- Xuejun Qin
- Duke Molecular Physiology Institute, Duke University Medical Center
- Kathryn P. Burdon
- Department of Ophthalmology, Flinders Medical Centre, Flinders University
- S. Amer Riazuddin
- The Wilmer Eye Institute, Johns Hopkins University School of Medicine
- Richard Mills
- Department of Ophthalmology, Flinders Medical Centre, Flinders University
- Sonja Klebe
- Department of Ophthalmology, Flinders Medical Centre, Flinders University
- Mollie A. Minear
- Duke Molecular Physiology Institute, Duke University Medical Center
- Jiagang Zhao
- Shiley Eye Institute, University of California
- Elmer Balajonda
- Duke University Eye Center, Duke University Medical Center
- George O. Rosenwasser
- Central Pennsylvania Eye Institute
- Keith H Baratz
- Department of Ophthalmology, Mayo Clinic
- V. Vinod Mootha
- Department of Ophthalmology, University of Texas Southwestern Medical Center
- Sanjay V. Patel
- Department of Ophthalmology, Mayo Clinic
- Simon G. Gregory
- Duke Molecular Physiology Institute, Duke University Medical Center
- Joan E. Bailey-Wilson
- Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health and Johns Hopkins University
- Marianne O. Price
- Price Vision Group
- Francis W. Price
- Price Vision Group
- Jamie E. Craig
- Department of Ophthalmology, Flinders Medical Centre, Flinders University
- John H. Fingert
- Department of Ophthalmology, University of Iowa, College of Medicine
- John D. Gottsch
- The Wilmer Eye Institute, Johns Hopkins University School of Medicine
- Anthony J. Aldave
- Stein Eye Institute, University of California
- Gordon K. Klintworth
- Duke University Eye Center, Duke University Medical Center
- Jonathan H. Lass
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Yi-Ju Li
- Duke Molecular Physiology Institute, Duke University Medical Center
- Sudha K. Iyengar
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- DOI
- https://doi.org/10.1038/ncomms14898
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism.
