Fibrinogen-to-Albumin Ratio is Associated with All-Cause Mortality in Cancer Patients

Abstract

Yanling Wen, Jingwen Yang, Xiaoyan Han Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, Zhejiang, 310003, People’s Republic of ChinaCorrespondence: Xiaoyan Han Email [email protected]: Past studies have identified fibrinogen-to-albumin ratio (FAR) as a novel prognostic immune biomarker in various diseases. Here, we investigated the prognostic value of FAR in all combined cancer mortality.Methods: We extracted patient data from the Multiparameter Intelligent Monitoring in Intensive Care Database III. FAR was measured prior to hospital admission. Only first admission data from each patient were used. Baseline data were extracted within 24 h after admission. The clinical endpoints were 90- and 365-day all-cause cancer mortality. Cox proportional hazards models and subgroup analyses were used to determine the relationship between FAR and these clinical endpoints.Results: A total of 652 eligible patients were enrolled. Upon adjusting for age and gender, multivariate analysis revealed correlation between higher FAR values and increased risk of all-cause mortality. After adjusting for more confounding factors, higher FAR values significantly correlated with 90- and 365-day all-cause mortality relative to low FAR values (tertile 3 vs tertile 1: HR, 95% CI: 1.65, 1.15– 2.39; 1.52, 1.10– 2.10).Conclusion: Our findings indicate that FAR may predict the risk of cancer mortality and is an independent prognostic indicator of all-cause mortality in cancer patients.Keywords: fibrinogen-to-albumin ratio, mortality, cancer, biomarker

Keywords

• fibrinogen-to-albumin ratio
• mortality
• cancer
• biomarker