The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review
Tae-Bin Yim,
Gyu-Ri Jeon,
Hye-Jin Lee,
Kyeong-Hwa Lee,
Hye-Min Heo,
Han-Gyul Lee,
Seungwon Kwon,
Seung-Yeon Cho,
Seong-Uk Park,
Woo-Sang Jung,
Sang-Kwan Moon,
Chang-Nam Ko,
Jung-Mi Park
Affiliations
Tae-Bin Yim
Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea
Gyu-Ri Jeon
Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea
Hye-Jin Lee
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, South Korea
Kyeong-Hwa Lee
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, South Korea
Hye-Min Heo
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, South Korea
Han-Gyul Lee
Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul, South Korea
Seungwon Kwon
Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea; Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul, South Korea
Seung-Yeon Cho
Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea
Seong-Uk Park
Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea
Woo-Sang Jung
Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea; Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul, South Korea
Sang-Kwan Moon
Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea; Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul, South Korea
Chang-Nam Ko
Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea
Jung-Mi Park
Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea; Corresponding author. Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
Background: and Purpose: The number of patients with cognitive impairment is increasing worldwide. Therapeutic drugs that slow disease progression are being developed; however, further research is required. This study investigated the effects of Kami Guibi-tang on patients with various types of cognitive decline. Methods: This study was a single-center, retrospective chart review of patients who visited KyungHee University Hospital at Gangdong from January 2015 to March 2022. The study included participants who took Kami Guibi-tang for more than 90 days and were assessed on the Korean version Mini-Mental State Examination (MMSE-K) scores before and after treatment. Participants who received other liquid herbal medicines during the treatment were excluded. The outcome of interest was changed scores in MMSE-K and Short form of Geriatric Depression Scale (S-GDS). Results: A total of 31 participants were included. The total MMSE-K score significantly increased with time and showed a significant increase at 3 and 9 months compared with baseline. Among the MMSE-K subscores, the orientation subscore showed a significant increase at three months compared with baseline, and the attention and calculation subscore showed a significant increase with time. In addition, four participants with vascular dementia showed a significant increase in the total MMSE-K score over time and a significant increase after 9 months compared with baseline. The S-GDS score in 31 participants showed a significant decrease with time and at all time points compared with baseline. Conclusions: Kami Guibi-tang may improve cognitive function in patients with cognitive decline.
