Reproductive and Developmental Medicine (Jan 2019)

Cyclooxygenase-2 and decidual immune cells

  • Si-Yao Ha,
  • Hui-Li Yang,
  • Zhen-Zhen Lai,
  • Lu-Yu Ruan,
  • Jia-Wei Shi,
  • Ming-Qing Li

DOI
https://doi.org/10.4103/2096-2924.268155
Journal volume & issue
Vol. 3, no. 3
pp. 177 – 184

Abstract

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Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in arachidonic acid (AA) metabolism. COX-2 and its products (prostanoids) serve versatile biological functions during pregnancy. Numerous evidences demonstrate special reprogramming of COX-2-catalyzing AA metabolism in decidual immune cells (DICs), particularly in decidual macrophages, corresponding to special gestational phases. This review summarizes the reprogramming of COX-2-catalyzing AA metabolism in DICs as well as the immunoregulation of diverse COX-2-generating prostanoids in DICs during the different phases of gestation.

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