The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters

Abstract

Objective:The pathogenesis and progression of osteoarthritis (OA) are related to low-grade inflammation. Objectives were conducted; first to investigate whether neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios are appropriate parameters to determine low-grade inflammation in knee OA. The second objective was to evaluate whether vitamin-D deficiency contributes to the severity of OA and these inflammatory parameters as well.Materials and Methods:623 patients with knee-pain were evaluated retrospectively, 136 patients with knee OA were included. 25-hidroxyvitamin D, complete-blood count, C-reactive protein, erythrocyte-sedimentation rate, knee radiographs (Kellgren-Lawrance scale) was recorded.Results:“Vitamin-D deficiency” was detected in 52.2% of all patients (<20 ng/mL). Blood parameters and severity of knee OA was found similar between patients with “25-hidroxyvitamin D <20 nanogramme/mililiters” and “≥20 nanogramme/mililiters.” 59.5% of patients had “mild OA,” 40.4% of patients had “moderate-to-severe OA.” All parameters were found similar between these two groups, only age was found significantly higher (p<0.001) in patients “moderate-to-severe OA.Conclusion:Neutrophil to lymphocyte, platelet to lymphocyte ratios are not found as appropriate parameters in determining low-grade-inflammation in knee OA; moreover there were found no relation between vitamin-D deficiency and both radiological severity and inflammation parameters in knee OA.

Keywords

• inflammation
• knee osteoarthritis
• vitamin d