Current HLA Investigations on SARS-CoV-2 and Perspectives

Venceslas Douillard; Erick C. Castelli; Steven J. Mack; Jill A. Hollenbach; Pierre-Antoine Gourraud; Nicolas Vince; Sophie Limou; Sophie Limou; for the Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium

doi:10.3389/fgene.2021.774922

Frontiers in Genetics (Nov 2021)

Current HLA Investigations on SARS-CoV-2 and Perspectives

Venceslas Douillard,
Erick C. Castelli,
Steven J. Mack,
Jill A. Hollenbach,
Pierre-Antoine Gourraud,
Nicolas Vince,
Sophie Limou,
Sophie Limou,
for the Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium

Affiliations

Venceslas Douillard: Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
Erick C. Castelli: Unesp - Universidade Estadual Paulista, Botucatu-SP, Brazil
Steven J. Mack: Division of Allergy, Immunology and Bone Marrow Transplantation, Department of Pediatrics, School of Medicine, University of California, San Francisco, CA, United States
Jill A. Hollenbach: Department of Neurology, University of California, San Francisco and Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States
Pierre-Antoine Gourraud: Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
Nicolas Vince: Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
Sophie Limou: Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
Sophie Limou: Ecole Centrale de Nantes, Department of Computer Sciences and Mathematics in Biology, Nantes, France
for the Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium

DOI: https://doi.org/10.3389/fgene.2021.774922
Journal volume & issue: Vol. 12

Abstract

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The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

About the journal

Abstract

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