Study on the effect of sodium hyaluronate combined with loteprednol eye drops on the treatment of dry eye in children

Abstract

AIM:To study the effect and safety of sodium hyaluronate combined with loteprednol eye drops compared to pure sodium hyaluronate eye drops in the clinical treatment of dry eye in children. METHODS: From August 2014 to August 2016, 128 children(256 eyes)with water deficient dry eye treated with artificial tears in our hospital were randomly divided into two groups, 64 cases(128 eyes)in each, the combined group and the control group, according to the random number table method. The combined group was given sodium hyaluronate combined with loteprednol treatment; the control group was given simple treatment of sodium hyaluronate eye drops. Before and after treatment for 2 and 6wk for ocular surface analysis system(Keratograph 5M)examination, determination of tear break-up time(BUT), tear meniscus height(TMH), meibomian gland infrared photography, slit lamp observation of corneal fluorescein staining, the observation indexes were statistically analyzed. RESULTS: After 2wk of treatment, the TMH and BUT level of the two groups were all higher than those before treatment(P). The scores of meibomian gland score and corneal fluorescein staining were lower than those before treatment, and the difference was statistically significant(PPPP>0.05). CONCLUSION: Sodium hyaluronate combined with loteprednol eye drops is more effective in the clinical treatment of dry eye children than the use of sodium hyaluronate eye drops, while the safety and tolerance are better.

Keywords

• artificial tears
• child
• dry eye
• dry eye