Electrochemical Determination of Epinephrine in Pharmaceutical Preparation Using Laponite Clay-Modified Graphene Inkjet-Printed Electrode

Chancellin Nkepdep Pecheu; Victor Kougoum Tchieda; Kevin Yemele Tajeu; Sherman Lesly Zambou Jiokeng; Andreas Lesch; Ignas Kenfack Tonle; Emmanuel Ngameni; Christoph Janiak

doi:10.3390/molecules28145487

Molecules (Jul 2023)

Electrochemical Determination of Epinephrine in Pharmaceutical Preparation Using Laponite Clay-Modified Graphene Inkjet-Printed Electrode

Chancellin Nkepdep Pecheu,
Victor Kougoum Tchieda,
Kevin Yemele Tajeu,
Sherman Lesly Zambou Jiokeng,
Andreas Lesch,
Ignas Kenfack Tonle,
Emmanuel Ngameni,
Christoph Janiak

Affiliations

Chancellin Nkepdep Pecheu: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, Dschang P.O. Box 67, Cameroon
Victor Kougoum Tchieda: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, Dschang P.O. Box 67, Cameroon
Kevin Yemele Tajeu: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, Dschang P.O. Box 67, Cameroon
Sherman Lesly Zambou Jiokeng: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, Dschang P.O. Box 67, Cameroon
Andreas Lesch: Department of Industrial Chemistry “Toso Montanari”, University of Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy
Ignas Kenfack Tonle: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, Dschang P.O. Box 67, Cameroon
Emmanuel Ngameni: Laboratory of Analytical Chemistry, Faculty of Science, The University of Yaounde 1, Yaounde P.O. Box 812, Cameroon
Christoph Janiak: Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine-Universität Düsseldorf, 40204 Düsseldorf, Germany

DOI: https://doi.org/10.3390/molecules28145487
Journal volume & issue: Vol. 28, no. 14
p. 5487

Abstract

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Epinephrine (EP, also called adrenaline) is a compound belonging to the catecholamine neurotransmitter family. It can cause neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. This work describes an amperometric sensor for the electroanalytical detection of EP by using an inkjet-printed graphene electrode (IPGE) that has been chemically modified by a thin layer of a laponite (La) clay mineral. The ion exchange properties and permeability of the chemically modified electrode (denoted La/IPGE) were evaluated using multi-sweep cyclic voltammetry, while its charge transfer resistance was determined by electrochemical impedance spectroscopy. The results showed that La/IPGE exhibited higher sensitivity to EP compared to the bare IPGE. The developed sensor was directly applied for the determination of EP in aqueous solution using differential pulse voltammetry. Under optimized conditions, a linear calibration graph was obtained in the concentration range between 0.8 µM and 10 μM. The anodic peak current of EP was directly proportional to its concentration, leading to detection limits of 0.34 μM and 0.26 μM with bare IPGE and La/IPGE, respectively. The sensor was successfully applied for the determination of EP in pharmaceutical preparations. Recovery rates and the effects of interfering species on the detection of EP were evaluated to highlight the selectivity of the elaborated sensor.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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