Emerging role of exosome-derived non-coding RNAs in tumor-associated angiogenesis of tumor microenvironment

Sai-Li Duan; Sai-Li Duan; Wei-Jie Fu; Ying-Ke Jiang; Lu-Shan Peng; Diabate Ousmane; Diabate Ousmane; Zhe-Jia Zhang; Zhe-Jia Zhang; Jun-Pu Wang; Jun-Pu Wang; Jun-Pu Wang; Jun-Pu Wang

doi:10.3389/fmolb.2023.1220193

Frontiers in Molecular Biosciences (Aug 2023)

Emerging role of exosome-derived non-coding RNAs in tumor-associated angiogenesis of tumor microenvironment

Sai-Li Duan,
Sai-Li Duan,
Wei-Jie Fu,
Ying-Ke Jiang,
Lu-Shan Peng,
Diabate Ousmane,
Diabate Ousmane,
Zhe-Jia Zhang,
Zhe-Jia Zhang,
Jun-Pu Wang,
Jun-Pu Wang,
Jun-Pu Wang,
Jun-Pu Wang

Affiliations

Sai-Li Duan: Department of General Surgery, Xiangya Hospital Central South University, Changsha, China
Sai-Li Duan: Xiangya School of Medicine, Central South University, Changsha, China
Wei-Jie Fu: Xiangya School of Medicine, Central South University, Changsha, China
Ying-Ke Jiang: Department of General Surgery, Xiangya Hospital Central South University, Changsha, China
Lu-Shan Peng: Department of Pathology, Xiang-ya Hospital, Central South University, Changsha, China
Diabate Ousmane: Xiangya School of Medicine, Central South University, Changsha, China
Diabate Ousmane: Department of Pathology, Xiang-ya Hospital, Central South University, Changsha, China
Zhe-Jia Zhang: Department of General Surgery, Xiangya Hospital Central South University, Changsha, China
Zhe-Jia Zhang: Xiangya School of Medicine, Central South University, Changsha, China
Jun-Pu Wang: Xiangya School of Medicine, Central South University, Changsha, China
Jun-Pu Wang: Department of Pathology, Xiang-ya Hospital, Central South University, Changsha, China
Jun-Pu Wang: Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China
Jun-Pu Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fmolb.2023.1220193
Journal volume & issue: Vol. 10

Abstract

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The tumor microenvironment (TME) is an intricate ecosystem that is actively involved in various stages of cancer occurrence and development. Some characteristics of tumor biological behavior, such as proliferation, migration, invasion, inhibition of apoptosis, immune escape, angiogenesis, and metabolic reprogramming, are affected by TME. Studies have shown that non-coding RNAs, especially long-chain non-coding RNAs and microRNAs in cancer-derived exosomes, facilitate intercellular communication as a mechanism for regulating angiogenesis. They stimulate tumor growth, as well as angiogenesis, metastasis, and reprogramming of the TME. Exploring the relationship between exogenous non-coding RNAs and tumor-associated endothelial cells, as well as their role in angiogenesis, clinicians will gain new insights into treatment as a result.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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