Progress on the role of cardiac-specific microRNA in myocardial infarction

Abstract

Cardiac-specific miRNAs, such as miR-1, miR-133, miR499 and miR208, are widely involved in cardiogenesis, physiology and pathology of heart. Cardiac-specific miRNAs are not only involved in cardiomyocyte differentiation in early cardiogenic stages and cardiomyocyte proliferation in the late cardiogenic stages, but also in cell damage or protection, fibrosis, and ventricular remodeling in myocardial infarction (MI) after birth. Meanwhile, cardiac-specific miRNAs can mobilize bone marrow stem cells into the peripheral blood, and promote heart repair and regeneration. In addition, circulating level of cardiac-specific miRNAs are significantly elevated after MI, which makes them to be a promising diagnostic marker for early diagnosis of acute MI.

Keywords

• cardiac-specific micrornas|myocardial infarction|myocardial protection|tissue regeneration