mBio (Oct 2021)
SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
- Yongzhen Liu,
- Chao Qin,
- Youliang Rao,
- Chau Ngo,
- Joshua J. Feng,
- Jun Zhao,
- Shu Zhang,
- Ting-Yu Wang,
- Jessica Carriere,
- Ali Can Savas,
- Mehrnaz Zarinfar,
- Stephanie Rice,
- Hanging Yang,
- Weiming Yuan,
- Julio A. Camarero,
- Jianhua Yu,
- Xiaojiang S. Chen,
- Chao Zhang,
- Pinghui Feng
Affiliations
- Yongzhen Liu
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Chao Qin
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Youliang Rao
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Chau Ngo
- Department of Chemistry, Dornsife College of Arts, Letters, and Sciences, University of Southern California, Los Angeles, California, USA
- Joshua J. Feng
- Department of Chemistry, Dornsife College of Arts, Letters, and Sciences, University of Southern California, Los Angeles, California, USA
- Jun Zhao
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Shu Zhang
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Ting-Yu Wang
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Jessica Carriere
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Ali Can Savas
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Mehrnaz Zarinfar
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Stephanie Rice
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- Hanging Yang
- Molecular and Computational Biology Section, University of Southern California, Los Angeles, California, USA
- Weiming Yuan
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, California, USA
- Julio A. Camarero
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA
- Jianhua Yu
- Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA
- Xiaojiang S. Chen
- Molecular and Computational Biology Section, University of Southern California, Los Angeles, California, USA
- Chao Zhang
- Department of Chemistry, Dornsife College of Arts, Letters, and Sciences, University of Southern California, Los Angeles, California, USA
- Pinghui Feng
- ORCiD
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
- DOI
- https://doi.org/10.1128/mBio.02335-21
- Journal volume & issue
-
Vol. 12,
no. 5
Abstract
The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral agents provides new avenues to prevent and treat COVID-19 diseases. This study describes a molecular characterization of innate immune evasion mediated by the SARS-CoV-2 Nsp5 main protease and subsequent development of a small-molecule inhibitor.
