Nature Communications (Nov 2020)

Computationally predicting clinical drug combination efficacy with cancer cell line screens and independent drug action

  • Alexander Ling,
  • R. Stephanie Huang

DOI
https://doi.org/10.1038/s41467-020-19563-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Computational models that can predict drug combination efficacy are often based on drug synergy. Here, the authors develop a different approach to computationally predict the efficacy of drug combinations using monotherapy data from high-throughput cancer cell line screens.