Nature Communications (May 2020)
A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis
- Stephen B. Freedman,
- Jianling Xie,
- Alberto Nettel-Aguirre,
- Xiao-Li Pang,
- Linda Chui,
- Sarah Williamson-Urquhart,
- David Schnadower,
- Suzanne Schuh,
- Philip M. Sherman,
- Bonita E. Lee,
- Serge Gouin,
- Ken J. Farion,
- Naveen Poonai,
- Katrina F. Hurley,
- Yuanyuan Qiu,
- Binal Ghandi,
- Colin Lloyd,
- Yaron Finkelstein,
- the Pediatric Emergency Research Canada Probiotic (PERC) Regimen for Outpatient Gastroenteritis Utility of Treatment (PROGUT) Trial Group
Affiliations
- Stephen B. Freedman
- Alberta Children’s Hospital Foundation Professor in Child Health and Wellness, Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary
- Jianling Xie
- Alberta Children’s Hospital Foundation Professor in Child Health and Wellness, Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary
- Alberto Nettel-Aguirre
- Alberta Children’s Hospital Foundation Professor in Child Health and Wellness, Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary
- Xiao-Li Pang
- University of Alberta, 116 St & 85 Ave.
- Linda Chui
- University of Alberta, 116 St & 85 Ave.
- Sarah Williamson-Urquhart
- Alberta Children’s Hospital Foundation Professor in Child Health and Wellness, Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary
- David Schnadower
- University of Cincinnati, 3333 Burnet Ave
- Suzanne Schuh
- University of Toronto, 555 University Avenue
- Philip M. Sherman
- University of Toronto, 555 University Avenue
- Bonita E. Lee
- University of Alberta, 116 St & 85 Ave.
- Serge Gouin
- Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine
- Ken J. Farion
- University of Ottawa, 401 Smyth Rd
- Naveen Poonai
- University of Western Ontario, 800 Commissioners Road E
- Katrina F. Hurley
- Dalhousie University, 5980 University Avenue, PO Box 9700
- Yuanyuan Qiu
- University of Alberta, 116 St & 85 Ave.
- Binal Ghandi
- University of Alberta, 116 St & 85 Ave.
- Colin Lloyd
- University of Alberta, 116 St & 85 Ave.
- Yaron Finkelstein
- University of Toronto, 555 University Avenue
- the Pediatric Emergency Research Canada Probiotic (PERC) Regimen for Outpatient Gastroenteritis Utility of Treatment (PROGUT) Trial Group
- DOI
- https://doi.org/10.1038/s41467-020-16308-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Here, the authors report the results of a randomized, placebo controlled trial of children with acute gastroenteritis who were treated with a probiotic and find no virus-specific beneficial effects attributable to the probiotic, either in reducing clinical symptoms or clearance of viral nucleic acid from stool specimens.
