Synthesis, characterization and study of antibacterial activity of some novel tetrazole derivatives

Abstract

This work aims at synthesizing novel tetrazole derivatives from phenothiazine. Phenothiazine is first converted into corresponding nitrile by reacting it with aldehyde, sodium metabisulphite and sodium cyanide. The nitrile on treatment with NaN3/DMF yielded the tetrazole derivative. In this work two tetrazole derivatives, viz., Dimethyl-{4-[phenothiazin-10-yl-(1H-tetrazol-5-yl)methyl]-phenyl}-amine and 10-[(4-Methoxy-phenyl)-(1H-tetrazole-5-yl)-methyl-10H-phenothiazine were prepared. The compounds were synthesized in good yields and their structures were confirmed by IR, 1H-NMR, mass and elemental analysis. The tetrazole compounds were screened for antimicrobial activity against bacteria and fungi. The results of the study show that the compounds present good antimicrobial activity.

Keywords

• phenothiazine
• nitrile
• tetrazole
• antibacterial activity