New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of <i>Chrysanthemum morifolium</i> and Their Bioactivities
Peng-Fei Yang,
Ya-Nan Yang,
Chun-Yu He,
Zhi-Fei Chen,
Qi-Shan Yuan,
Sheng-Chen Zhao,
Yu-Feng Fu,
Pei-Cheng Zhang,
Duo-Bin Mao
Affiliations
Peng-Fei Yang
College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, China
Ya-Nan Yang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Chun-Yu He
College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, China
Zhi-Fei Chen
Technology Center, China Tobacco Henan Industrial Co. Ltd., Zhengzhou 450000, China
Qi-Shan Yuan
Technology Center, China Tobacco Henan Industrial Co. Ltd., Zhengzhou 450000, China
Sheng-Chen Zhao
Technology Center, China Tobacco Henan Industrial Co. Ltd., Zhengzhou 450000, China
Yu-Feng Fu
Technology Center, China Tobacco Henan Industrial Co. Ltd., Zhengzhou 450000, China
Pei-Cheng Zhang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Duo-Bin Mao
College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, China
The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (1, 2), a new flavanone glycoside (3), and six reported flavanones (4⁻9) were isolated and identified from the flowers of C. morifolium. The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents 1⁻8 were evaluated for their neuroprotective activity, and compounds 3 and 4 displayed neuroprotective effects against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.
