Frontiers in Oncology (Jul 2021)

Real Life Clinical Management and Survival in Advanced Cutaneous Melanoma: The Italian Clinical National Melanoma Registry Experience

  • Anna Crispo,
  • Maria Teresa Corradin,
  • Erika Giulioni,
  • Antonella Vecchiato,
  • Paolo Del Fiore,
  • Paola Queirolo,
  • Paola Queirolo,
  • Francesco Spagnolo,
  • Vito Vanella,
  • Corrado Caracò,
  • Giulio Tosti,
  • Elisabetta Pennacchioli,
  • Giuseppe Giudice,
  • Eleonora Nacchiero,
  • Pietro Quaglino,
  • Simone Ribero,
  • Monica Giordano,
  • Desire Marussi,
  • Stefania Barruscotti,
  • Michele Guida,
  • Vincenzo De Giorgi,
  • Marcella Occelli,
  • Federica Grosso,
  • Giuseppe Cairo,
  • Alessandro Gatti,
  • Daniela Massa,
  • Laura Atzori,
  • Nicola Calvani,
  • Tommaso Fabrizio,
  • Giuseppe Mastrangelo,
  • Federica Toffolutti,
  • Egidio Celentano,
  • Mario Budroni,
  • Sara Gandini,
  • Carlo Riccardo Rossi,
  • Carlo Riccardo Rossi,
  • Alessandro Testori,
  • Giuseppe Palmieri,
  • Paolo A. Ascierto,
  • the Clinical National Melanoma Registry Study Group at the Italian Melanoma Intergroup,
  • Maddalena Cespa,
  • Rosachiara Forcignanò,
  • Gianmichele Moise,
  • Maria Concetta Fargnoli,
  • Caterina Ferreli,
  • Maria Grimaldi,
  • Guido Zannetti,
  • Saverio Cinieri,
  • Giusto Trevisan,
  • Ignazio Stanganelli,
  • Giovanna Moretti,
  • Francesca Bruder,
  • Luca Bianchi,
  • Maria Teresa Fierro,
  • Luigi Mascheroni,
  • Salvatore Asero,
  • Caterina Catricalà,
  • Stefania Staibano,
  • Gaetana Rinaldi,
  • Riccardo Pellicano,
  • Laura Milesi,
  • Marilena Visini,
  • Franco Di Filippo,
  • Leonardo Zichichi,
  • Maria Antonietta Pizzichetta,
  • Carmelo Iacono,
  • Massimo Guidoboni,
  • Giovanni Sanna,
  • Michele Maio,
  • Lucia Lospalluti,
  • Rosanna Barbati,
  • Leonardi Vita,
  • Annamaria Pollio,
  • Carlo Riberti

DOI
https://doi.org/10.3389/fonc.2021.672797
Journal volume & issue
Vol. 11

Abstract

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BackgroundCutaneous melanoma (CM) is one of the most aggressive types of skin cancer. Currently, innovative approaches such as target therapies and immunotherapies have been introduced in clinical practice. Data of clinical trials and real life studies that evaluate the outcomes of these therapeutic associations are necessary to establish their clinical utility. The aim of this study is to investigate the types of oncological treatments employed in the real-life clinical management of patients with advanced CM in several Italian centers, which are part of the Clinical National Melanoma Registry (CNMR).MethodsMelanoma-specific survival and overall survival were calculated. Multivariate Cox regression models were used to estimate the hazard ratios adjusting for confounders and other prognostic factors.ResultsThe median follow-up time was 36 months (range 1.2-185.1). 787 CM were included in the analysis with completed information about therapies. All types of immunotherapy showed a significant improved survival compared with all other therapies (p=0.001). 75% was the highest reduction of death reached by anti-PD-1 (HR=0.25), globally immunotherapy was significantly associated with improved survival, either for anti-CTLA4 monotherapy or combined with anti-PD-1 (HR=0.47 and 0.26, respectively) and BRAFI+MEKI (HR=0.62).ConclusionsThe nivolumab/pembrolizumab in combination of ipilimumab and the addition of ant-MEK to the BRAFi can be considered the best therapies to improve survival in a real-world-population. The CNMR can complement clinical registries with the intent of improving cancer management and standardizing cancer treatment.

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