Antihyperlipidemic effect of Adonis vernalis

Abstract

Objective To study the effect of Adonis vernalis on triton-induced hyperlipidemic rabbits. Hyperlipidemia has become a major risk factor for a large variety of diseases including coronary artery disease and thus increasing mortality ratio globally. A. vernalis (AV) commonly called as Pheasant eye is a Homoeopathic remedy and considered as cardiotonic due to presence of cardiac gylcosides with strong diuretic action. Study Design & Methods The present study investigates the hyperlipidemic effects of Adonis vernalis in chemically (triton; 400 mg/kg intraperitoneally) induced hyperlipidemic rabbits. Its effects on lipid profile, glucose, total protein, serum uric acid and liver specific enzyme alanine aminotransferase (ALT) were determined by administering alcoholic extract of A. vernalis (5 mg/kg) orally and compared against respective control groups. Results AV (5 mg/kg) had shown a significant decrease in serum cholesterol and triglycerides when compared with control, triton-induced hyperlipidemic control (TIC) and triton-induced positive control (TIPC) (p<0.05). It slightly increased HDL, clear decrease in LDL and total protein while no effect was found on ALT, uric acid and glucose. Conclusions According to the experimental findings the alcoholic extract of A. vernalis found to be a potent antihyperlipidemic agent and also showed hepatoprotective property.

Keywords

• hyperlipidemia
• coronary artery disease
• cardiotonic
• cardiac glycoside
• diuretic
• antihyperlipidemic
• hepatoprotective