Nature Communications (Jul 2019)

Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli

  • Mattia Zampieri,
  • Manuel Hörl,
  • Florian Hotz,
  • Nicola F. Müller,
  • Uwe Sauer

DOI
https://doi.org/10.1038/s41467-019-11331-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Bacteria must adapt their metabolism in the face of dynamically changing nutrient availability. Here, using their constraint-based modeling approach the authors analyze E. coli exometabolome data during growth in complex medium, revealing temporal coordination of glucose and amino acid catabolism.