A gut feeling for drugs that have metabolic benefits

Eryun Zhang; Alon Agua; Wendong Huang

doi:10.1038/s41467-023-40167-3

Nature Communications (Jul 2023)

A gut feeling for drugs that have metabolic benefits

Eryun Zhang,
Alon Agua,
Wendong Huang

Affiliations

Eryun Zhang: Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Alon Agua: Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Wendong Huang: Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center

DOI: https://doi.org/10.1038/s41467-023-40167-3
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 4

Abstract

Read online

Resveratrol (REV) is a natural polyphenol with anti-obesity effects. However, the mechanisms remain unclear due to its low bioavailability and the lack of defined membrane-bound or nuclear receptors. Pang and colleagues reported that REV intervention (REV-I) alters gut microbiota and bile acid profile, leading to the inhibition of farnesoid X receptor (FXR) and attenuation of scavenger receptor class B type 1 (SR-B1)-mediated chylomicron secretion. This highlights a therapeutic potential of targeting gut microbiome and intestinal SR-B1 for obesity and diabetes treatment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal