DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis

• Qiuxia Cui,
• Jian Sun,
• Jingping Yuan,
• Juanjuan Li,
• Chuanyu Yang,
• Guangshi Du,
• Chengang Zhou,
• Pu Qiu,
• Jidong Gao,
• Yuanqi Zhang,
• Dewei Jiang,
• Ceshi Chen

Affiliations

Qiuxia Cui

Affiliated Hospital of Guangdong Medical University Science & Technology of China, Zhanjiang, Guangdong 524000, China; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, China; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China

Jian Sun

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Jingping Yuan

Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China

Juanjuan Li

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China

Chuanyu Yang

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China

Guangshi Du

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Translational Medicine Research Center of Guizhou Medical University, Guiyang, Guizhou 550025, China

Chengang Zhou

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China

Pu Qiu

Affiliated Hospital of Guangdong Medical University Science & Technology of China, Zhanjiang, Guangdong 524000, China

Jidong Gao

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, China

Yuanqi Zhang

Affiliated Hospital of Guangdong Medical University Science & Technology of China, Zhanjiang, Guangdong 524000, China; Corresponding author. Academy of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, China.

Dewei Jiang

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Corresponding author. Academy of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, China.

Ceshi Chen

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Yunnan Cancer Hospital and the Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Center, Kunming, Yunnan 650500, China; Academy of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, China; Corresponding author. Academy of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, China.