Frontiers in Medicine (Jun 2021)

Early Life Microbial Exposure and Immunity Training Effects on Asthma Development and Progression

  • Andressa Daronco Cereta,
  • Vinícius Rosa Oliveira,
  • Vinícius Rosa Oliveira,
  • Ivan Peres Costa,
  • Letícia Lopes Guimarães,
  • João Pedro Ribeiro Afonso,
  • Adriano Luís Fonseca,
  • Alan Robson Trigueiro de Sousa,
  • Guilherme Augusto Moreira Silva,
  • Diego A. C. P. G. Mello,
  • Luis Vicente Franco de Oliveira,
  • Renata Kelly da Palma,
  • Renata Kelly da Palma,
  • Renata Kelly da Palma

DOI
https://doi.org/10.3389/fmed.2021.662262
Journal volume & issue
Vol. 8

Abstract

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Asthma is the most common inflammatory disease affecting the lungs, which can be caused by intrauterine or postnatal insults depending on the exposure to environmental factors. During early life, the exposure to different risk factors can influence the microbiome leading to undesired changes to the immune system. The modulations of the immunity, caused by dysbiosis during development, can increase the susceptibility to allergic diseases. On the other hand, immune training approaches during pregnancy can prevent allergic inflammatory diseases of the airways. In this review, we focus on evidence of risk factors in early life that can alter the development of lung immunity associated with dysbiosis, that leads to asthma and affect childhood and adult life. Furthermore, we discuss new ideas for potential prevention strategies that can be applied during pregnancy and postnatal period.

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