Detection of SEN virus (SEN-V) and Torque Teno virus (TTV) Co-Infection and Liver Enzyme in a Sample of Hepatitis Patients.

Abstract

is increase evidences suggested the existence of new hepatitis viruses that play a role in this disease. This study aimed to determine the synergistic effect of concordant infection with SEN virus and Torque Teno virus in patients with hepatitis and apparently healthy blood donors as control. Sera were collected from 50 patients who had hepatitis type B or C as a case group and from 50 apparently healthy blood donors as control. All samples were tested by polymerase chain reaction (PCR) for detection of SEN-V DNA, while TTV antigen were tested by immunoassay. In addition, ALT and AST enzymes have been tested using biochemical test. TTV and SEN-V co-infections had been detected in hepatitis patient and apparently healthy blood donors with exposure rate (26%) and (4.65%), respectively. Current study indicated that there were no significant differences between the mean level of ALT or AST enzymes and the SENV/TTV co-infection. Also, there was no significant associated between SENV/TTV co-infection and risk factors under study.

Keywords

• Liver disease, SEN-V, TTV, Hepatitis B virus, Hepatitis C virus. List of abbreviation: SEN-V = SEN virus, Torque Teno virus = TTV AST= Aspartate Aminotransferase, AST = Aspartate Aminotransferase