Xin yixue (Nov 2022)

Progress of hepatitis B virus-associated neutralizing antibody in antiviral therapy of chronic hepatitis B

  • Zhao Yudi, Huang Mingxing

DOI
https://doi.org/10.3969/j.issn.0253-9802.2022.11.003
Journal volume & issue
Vol. 53, no. 11
pp. 802 – 805

Abstract

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Chronic hepatitis B virus infection is not only an important global public health problem but also an important challenge in our country. Although there are some vaccines for hepatitis B and its prevalence is increasing year by year, there are still many patients in need of treatment. Neutralizing antibody as an important treatment for HIV is also promising in the field of hepatitis B cure. Current studies on neutralizing antibodies related to hepatitis B virus mainly include G12, Bc1.187, H017, H019, BX-182, KR127 and 2H5-A14, among which H017 and H019 combined application and 2H5-A14 have achieved quite good results in immune tolerance and neutralization activity in animal experiments. This article reviews the research progress of neutralizing antibodies related to hepatitis B virus to explore the possible development direction and application prospect in the future.

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