Computational Neuroscience and Cognitive Robotics Centre, University of Birmingham, Birmingham, United Kingdom; Institute of Psychology, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Institute of Neuroscience, Université Catholique de Louvain, Louvain-la-Neuve, Belgium
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Integrative Model-based Cognitive Neuroscience research unit, University of Amsterdam, Amsterdam, Netherlands
Robert Trampel
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Robert Turner
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom
Uta Noppeney
Computational Neuroscience and Cognitive Robotics Centre, University of Birmingham, Birmingham, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands
In our environment, our senses are bombarded with a myriad of signals, only a subset of which is relevant for our goals. Using sub-millimeter-resolution fMRI at 7T, we resolved BOLD-response and activation patterns across cortical depth in early sensory cortices to auditory, visual and audiovisual stimuli under auditory or visual attention. In visual cortices, auditory stimulation induced widespread inhibition irrespective of attention, whereas auditory relative to visual attention suppressed mainly central visual field representations. In auditory cortices, visual stimulation suppressed activations, but amplified responses to concurrent auditory stimuli, in a patchy topography. Critically, multisensory interactions in auditory cortices were stronger in deeper laminae, while attentional influences were greatest at the surface. These distinct depth-dependent profiles suggest that multisensory and attentional mechanisms regulate sensory processing via partly distinct circuitries. Our findings are crucial for understanding how the brain regulates information flow across senses to interact with our complex multisensory world.