Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes
Jing-chao Ren,
Huan Liu,
Guang-hui Zhang,
Tongshuai Wang,
Jingzhi Li,
Tingting Dong,
Hantian Wu,
Zhao-lin Xia
Affiliations
Jing-chao Ren
School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China
Huan Liu
School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China
Guang-hui Zhang
School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China; Corresponding authors.
Tongshuai Wang
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China
Jingzhi Li
School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China
Tingting Dong
School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China
Hantian Wu
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China
Zhao-lin Xia
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China; Corresponding authors.
In this paper, we present an occupational dataset to evaluate benzene exposure on the effective biomarkers of genetic damage, indicated as cytokinesis-block micronucleus (MN) frequency, hematotoxicity, indicated as white blood cells (WBC) counts, and molecular marker of telomere length (TL). And we further to eliminate the mechanism of benzene induced damage. Then evaluate the effects of sites polymorphism in environmental response genes, including 18 sites in metabolic and DNA repair genes, and the interaction between gene polymorphism and benzene exposure. This dataset is supplementary to the submitted research by [1] focused on the biomarkers TL, and a detailed description of the subjects sampling, biomarkers detection, data analysis and discussion are discussed in detail.
