Six New Phragmalin Limonoids from the Stems of <i>Chukrasia tabularis</i> A. Juss

Abstract

Six new phragmalin limonoids, named moluccensin Z1 (1), moluccensin Z2 (2), carapanolide Y (3), tabulalin N (4), chukvelutilide A1 (5), and velutinasin J (6), as well as two known compounds, chukvelutilide A (7) and velutinasin D (8) were isolated from the stems of Chukrasia tabularis A. Juss. The structures of the new compounds 1⁻6 were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for α-glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against α-glucosidase and acetylcholinesterase in vitro.

Keywords

• <i>Chukrasia tabularis</i> A. Juss
• Meliaceae
• phragmalin limonoid
• α-glucosidase inhibition activity
• acetylcholinesterase inhibitory activity