PECULIARITIES OF IMMUNOREACTIVITY OF ORGANISM OF EMPLOYEES WORKING IN CONDITIONS OF EXPOSURE OF NEUROTOXICANTS OF DIFFERENT CHEMICAL NATURE

Abstract

The different forms and the degree of expression of the immune responses of the employees to the exposure to the neurotoxicants of different chemical nature (metallic mercury vapours, vinyl chloride and dichloroethane, epichlorohydrin and. allyl chloride), stipulated, mainly by the specific character of chemical factor, were revealed. The role of pro- and. anti-inflammatory cytokines in the immune regulation, processes was indicated to be in the exposure to the neurotoxicants. The pro- inflammatory trend, of the responses of different intensity without the dependence on the exposure factor was considered, as the common change regularity of the cytokine profile in the persons of the "risk group". The peculiarities of the immunoresponsiveness changes in dependence on the working period, duration (record of service) under the harmful working conditions displaying the different immune mechanisms in exposure to the harmful production, substances (metallic mercury vapours, vinyl chloride and. dichloroethane, epichlorohydrin. and. allyl chloride) were revealed.

Keywords

• employees
• immunological responsiveness
• neurotoxicants