How autophagy is tied to inflammation and cancer

Abstract

It is not completely understood how autophagy is tied to inflammation and age-related cancer predisposition. Here, we used a mouse model with inducible expression of a cancer-derived frameshift mutation in UV radiation resistance associated (UVRAG) to demonstrate that intervention with autophagy suppressor could exacerbate inflammation and promote age-related spontaneous cancers.

Keywords

• uvrag
• autophagy
• inflammation
• β-catenin
• centrosome
• tumorigenesis