Phenotypic Characteristics and Antibiotic Resistance Patterns of Most Common Nosocomial Pathogens in Noor Hospital, Isfahan, Iran

Abstract

Background: Nosocomial infection is a serious problem in medical science that expends a lot of money and prolongation of treatment of the patient. This study was done to find the main causes of nosocomial infection in Isfahan and their antimicrobial resistance. Methods: In this study, 108 admitted patients suspected of nosocomial infections were studied. The patients were admitted in different wards of Isfahan Noor hospital. Blood, urine, ulcer or nasal sample were sent to the laboratory for diagnosis and designing antimicrobial resistance pattern. After purification and determination of bacterial type and the disk diffusion method, E. Test, antibiotic susceptibility testing was performed. Data were analyzed by SPSS software. Results: The gram-positive bacteria, particularly Staphylococcus aureus resistant to ceftriaxone, cotrimoxazole, and cefotaxime hundred percentage and have high sensitivity to vancomycin. The high resistance among gram-negative bacteria to antibiotics investigated in this project, including ceftriaxone, cotrimoxazole and cefotaxime has been seen. Conclusion: The results obtained in this project showed the high resistance of gram-positive and gram negative isolates to the commonly recommended antibiotics. Therefore, preventive interventions of nasocomial infection should be used. In addition, consumption of antibiotics should be restricted and proper administration of sensitive antibiotics affecting Staphylococcus aureus such as vancomycin is recommended.

Keywords

• Nosocomial Infection
• Antibiogram
• E. Test