Palladium-catalyzed cyclobutenation of aryl chlorides with norbornenes

Zhenkun Chen; Mingruo Ding; Haobin Jiang; Fengzhi Zhang

Green Synthesis and Catalysis (Feb 2022)

Palladium-catalyzed cyclobutenation of aryl chlorides with norbornenes

Zhenkun Chen,
Mingruo Ding,
Haobin Jiang,
Fengzhi Zhang

Affiliations

Zhenkun Chen: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China
Mingruo Ding: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China
Haobin Jiang: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China
Fengzhi Zhang: Corresponding author.; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China

Journal volume & issue: Vol. 3, no. 1
pp. 79 – 83

Abstract

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A palladium-catalyzed cyclobutenation of readily available aryl chlorides and norbornene derivatives is reported here. Under the optimum reaction conditions, various valuable benzocyclobutene derivatives were prepared efficiently via Heck-Catellani reaction. The key is the employment of bulky t-Bu3PHBF4 phosphine ligand which promoted C–C reductive elimination from the palladacycle.

Published in Green Synthesis and Catalysis

ISSN: 2666-5549 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/green-synthesis-and-catalysis/

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