Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection

Jessica Radzio-Basu; Olivia Council; Mian-er Cong; Susan Ruone; Alicia Newton; Xierong Wei; James Mitchell; Shanon Ellis; Christos J. Petropoulos; Wei Huang; William Spreen; Walid Heneine; J. Gerardo García-Lerma

doi:10.1038/s41467-019-10047-w

Nature Communications (May 2019)

Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection

Jessica Radzio-Basu,
Olivia Council,
Mian-er Cong,
Susan Ruone,
Alicia Newton,
Xierong Wei,
James Mitchell,
Shanon Ellis,
Christos J. Petropoulos,
Wei Huang,
William Spreen,
Walid Heneine,
J. Gerardo García-Lerma

Affiliations

Jessica Radzio-Basu: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Olivia Council: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Mian-er Cong: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Susan Ruone: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Alicia Newton: Monogram Biosciences
Xierong Wei: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
James Mitchell: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Shanon Ellis: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Christos J. Petropoulos: Monogram Biosciences
Wei Huang: Monogram Biosciences
William Spreen: ViiV Healthcare
Walid Heneine: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
J. Gerardo García-Lerma: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention

DOI: https://doi.org/10.1038/s41467-019-10047-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Long-acting formulation of the integrase inhibitor cabotegravir (CAB LA) is in clinical development for HIV pre-exposure prophylaxis (PrEP). Here, using a SHIV macaque model, the authors show emergence of integrase mutations associated to CAB LA PrEP that confer pan-integrase inhibitor resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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