Gut Pathogens (Oct 2024)
Infectious etiology of intussusception in Indian children less than 2 years old: a matched case-control analysis
- Ira Praharaj,
- Samarasimha Nusi Reddy,
- Nayana Prabhakaran Nair,
- Jacqueline Elizabeth Tate,
- Sidhartha Giri,
- Varunkumar Thiyagarajan,
- Venkata Raghava Mohan,
- Rajendiran Revathi,
- Kalaivanan Maheshwari,
- Priya Hemavathy,
- Nirmal Kumar,
- Mohan Digambar Gupte,
- Rashmi Arora,
- Sowmiya Senthamizh,
- Suhasini Mekala,
- Krishna Babu Goru,
- Padmalatha Pamu,
- Manohar Badur,
- Subal Pradhan,
- Mrutunjay Dash,
- Nirmal Kumar Mohakud,
- Rajib Kumar Ray,
- Geetha Gathwala,
- Madhu Gupta,
- Ravi Kanojia,
- Rajkumar Gupta,
- Suresh Goyal,
- Pramod Sharma,
- Mannancheril Abraham Mathew,
- Tarun John Kochukaleekal Jacob,
- Balasubramanian Sundaram,
- Chethrapilly Purusothaman Girish Kumar,
- Priyadarshini Dorairaj,
- Ramasubramaniam Pitchumani,
- Raghul Maniam,
- Sambandan Kumaravel,
- Hemant Jain,
- Jayanta Kumar Goswami,
- Ashish Wakhlu,
- Vineeta Gupta,
- Jie Liu,
- Eric R. Houpt,
- Umesh D. Parashar,
- Gagandeep Kang
Affiliations
- Ira Praharaj
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Samarasimha Nusi Reddy
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Nayana Prabhakaran Nair
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Jacqueline Elizabeth Tate
- Centers for Disease Control and Prevention
- Sidhartha Giri
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Varunkumar Thiyagarajan
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Venkata Raghava Mohan
- Department of Community Health, Christian Medical College
- Rajendiran Revathi
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Kalaivanan Maheshwari
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Priya Hemavathy
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Nirmal Kumar
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Mohan Digambar Gupte
- Translational Health Science and Technology Institute
- Rashmi Arora
- Translational Health Science and Technology Institute
- Sowmiya Senthamizh
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Suhasini Mekala
- Kurnool Medical College and Government General Hospital
- Krishna Babu Goru
- Government General Hospital and Rangaraya Medical College
- Padmalatha Pamu
- King George Hospital and Andhra Medical College
- Manohar Badur
- Sri Venkateshwara Medical College
- Subal Pradhan
- Sardar Vallabh Bhai Patel Post Graduate Institute of Paediatrics
- Mrutunjay Dash
- Institute of Medical Sciences, SUM Hospital
- Nirmal Kumar Mohakud
- Kalinga Institute of Medical Sciences
- Rajib Kumar Ray
- Hi-Tech Hospital
- Geetha Gathwala
- Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
- Madhu Gupta
- Post Graduate Institute of Medical Education and Research
- Ravi Kanojia
- Post Graduate Institute of Medical Education and Research
- Rajkumar Gupta
- Sawai Man Singh Medical College
- Suresh Goyal
- Rabindranath Tagore Medical College
- Pramod Sharma
- Dr. Sampurnanand Medical College
- Mannancheril Abraham Mathew
- Malankara Orthodox Syrian Church Medical College Hospital
- Tarun John Kochukaleekal Jacob
- Department of Pediatric Surgery, Christian Medical College
- Balasubramanian Sundaram
- Kanchi Kamakoti Child Trust Hospital
- Chethrapilly Purusothaman Girish Kumar
- National Institute of Epidemiology
- Priyadarshini Dorairaj
- Institute of Child Health
- Ramasubramaniam Pitchumani
- Government Rajaji Hospital and Madurai Medical College
- Raghul Maniam
- Coimbatore Medical College
- Sambandan Kumaravel
- Jawaharlal Nehru Institute of Post-graduate Medical Education & Research
- Hemant Jain
- Mahatma Gandhi Memorial Medical College
- Jayanta Kumar Goswami
- Government Medical College
- Ashish Wakhlu
- King George Medical College
- Vineeta Gupta
- Institute of Medical Sciences, Banaras Hindu University
- Jie Liu
- Division of Infectious Diseases and International Health, University of Virginia
- Eric R. Houpt
- Division of Infectious Diseases and International Health, University of Virginia
- Umesh D. Parashar
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- Gagandeep Kang
- The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College
- DOI
- https://doi.org/10.1186/s13099-024-00659-z
- Journal volume & issue
-
Vol. 16,
no. 1
pp. 1 – 9
Abstract
Abstract Background Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens. Methods In a case-control study nested within a large sentinel hospital-based surveillance program in India, stool samples from 272 children aged less than 2 years admitted for intussusception and 272 age-, gender- and location-matched controls were evaluated with Taqman array card based molecular assays to detect enteric viruses, bacterial enteropathogens and parasites. Matched case-control analysis with conditional logistic regression evaluated association of enteropathogens with intussusception. Population attributable fractions (PAF) were calculated for enteropathogens significantly associated with intussusception. Results The most prevalent enteropathogens in cases and controls were enteroaggregative Escherichia coli, adenovirus 40/41, adenovirus C serotypes and enteroviruses. Children with intussusception were more likely to harbor adenovirus C serotypes (adjusted odds-ratio (aOR) = 1.74; 95% confidence interval (CI) 1.06–2.87) and enteroviruses (aOR = 1.77; 95% CI 1.05–2.97) than controls. Rotavirus was not associated with increased intussusception risk. Adenovirus C (PAF = 16.9%; 95% CI 4.7% − 27.6%) and enteroviruses (PAF = 14.7%; 95% CI 4.2% − 24.1%) had the highest population attributable fraction for intussusception. Conclusion Adenovirus C serotypes and enteroviruses were significantly associated with intussusception in Indian children. Rotavirus was not associated with risk of intussusception.
Keywords