Revista do Instituto de Medicina Tropical de São Paulo (Dec 2017)

Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

  • Diego H. Cáceres,
  • Alejandra Zuluaga,
  • Ángela M. Tabares,
  • Tom Chiller,
  • Ángel González,
  • Beatriz L. Gómez

DOI
https://doi.org/10.1590/s1678-9946201759076
Journal volume & issue
Vol. 59, no. 0

Abstract

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ABSTRACT A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

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